Also provided are efficient remote film loading methods for loading the liposomes with the anti-cancer drugs and methods for treating cancer with the liposomal formulations. Background Rapamycin, also known as sirolimus, is a macrolide antibiotic initially developed for use as an immune suppressor for transplant patients. Subsequently, it was used as a drug coating for coronary artery stents, where it functions to reduce restenosis following angioplasty by inhibiting smooth muscle cell proliferation.
Ernst Schering Res Found Workshop New glucocorticoids on the horizon: Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes.
Pharmacokinetics of dexamethasone and its phosphate ester. Biopharm Drug Dispos Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: A new hypothesis of modular glucocorticoid actions: Glucocorticoids in the treatment of rheumatic diseases: Immunologische Grundlagen, Pharmakologie und Therapierichtlinien 2nd edition.
Wissenschaftliche Verlagsgesellschaft mbH; Interaction between the hypothalamo-pituitaryadrenal axis and the immunological system.
Ann Endocrinol Paris Exogenous Cushing's syndrome and glucocorticoid withdrawal. Endocrinol Metab Clin North Am Long-circulating liposomal prednisolone versus pulse intramuscular methylprednisolone in patients with active rheumatoid arthritis [abstract].
Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: Collagen-induced arthritis as a model of rheumatoid arthritis. Clin Immunol Immunopathol Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis.
Ann Rheum Dis Comparative properties and methods of preparation of lipid vesicles liposomes. Annu Rev Biophys Bioeng Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes.
Biochim Biophys Acta Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis.
New developments in the pathogenesis and treatment of steroid-induced osteoporosis.PEGylated liposomal methylpredniso-lone (2B) improves therapeutic efﬁcacy in a model of ocular inﬂam-mation. Invest Ophthalmol Vis Sci.
;– DOI/ iovs PURPOSE. Ocular inﬂammation is associated with the loss of visual acuity and subsequent blindness.
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a .
Gemcitabine-loaded pegylated unilamellar liposomes ( nm) were proposed for the treatment of multiple myeloma cancer disease. Physicochemical and technological parameters of liposomes were evaluated by using laser light scattering and gel permeation chromatography.
These PEGylated magnetic niosomes were also loaded with Carboplatin, an antitumor drug.
Next, these niosomes were studied in terms of size, morphology, zeta potential, and drug entrapment efficiency. Xavier, Seena Kanniparambil and Shoja, Muhammed Haneefa and Devkar, Raviraj Anand and Rao, Picheswara P and Maheshwari, Rajalekshmi and Shastry, Chandrashekara Shreedhara and Setty, Manjunath M () Antioxidant and Nephroprotective Activities of the Extract and Fractions of Homonoia riparia Lour.
Drug-loaded nanoparticles provide a perfect solution to afford higher therapeutic efficacy and/or reducing toxicity and the possibility of targeting cancer tissues. Nanoliposomes are one of the best drug delivery systems for low molecular weight drugs, imaging agents, peptides, proteins, and nucleic acids.
Gemcitabine-loaded pegylated unilamellar liposomes ( nm) were proposed for the treatment of multiple myeloma cancer disease. Physicochemical and technological parameters of liposomes were evaluated by using laser light scattering and gel permeation chromatography. These nanoliposomes were used to deliver Par-4 plasmid to tumors growing in nude mice from wild type HT29 cells. Results showed that nanoliposomes effectively delivered plasmid DNA to tumors in vivo. Again, tumors in mice treated with the Par-4 nanoliposomes were more susceptible to 5-FU treatment. Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application.